Evaluasi Aktivitas Hipoglikemik Infusa Daun Pare (Momordica charantia L.) pada Mencit Putih Jantan (Mus musculus)

Hendra Hariyadi; Novita Wulandari

Authors

Hendra Hariyadi Program Studi S1 Farmasi, Universitas Efarina, Sumatera Utara Author
Novita Wulandari Program Studi S1 Farmasi, Universitas Efarina, Sumatera Utara Author

Keywords:

Antidiabetic, Bitter Melon Leaves, Glibenclamide, Hyperglycemia, Momordica charantia L

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired carbohydrate metabolism. This study aims to evaluate the hypoglycemic activity of bitter melon (Momordica charantia L.) leaf infusion and determine the most effective concentration for reducing blood glucose levels. Using an experimental design, 15 male mice were divided into five treatment groups. The negative control group received 0.5% CMC, the positive control was administered a glibenclamide suspension, and the three test groups received bitter melon leaf infusion at concentrations of 10%, 15%, and 20%, respectively. Hyperglycemia was induced through glucose administration 30 minutes post-treatment, with blood glucose levels monitored every 15 minutes. The results indicated that bitter melon leaf infusion significantly lowered blood glucose levels in mice, with the 10% concentration already demonstrating notable efficacy

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